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09/14/11 2:00 PM ET

Indians' 2012 slate opens vs. Blue Jays

Cleveland's season begins and ends with six-game homestands

ARLINGTON -- The Indians will open the 2012 season with six straight games at Progressive Field, the first coming against the Blue Jays on April 5, according to the MLB schedule released on Wednesday.

Aside from the yearly home-and-home series against the Reds, the Indians will play the Marlins, Cardinals, Pirates and Astros in next season's Interleague slate.

Cleveland will visit Minute Maid Park for the second time in franchise history, first playing there in 2001, when the stadium was known as Enron Field.

After taking five of six in this year's series, the Indians renew their battle for the Ohio Cup against the Reds on June 12-14 in Cincinnati, and then play them back home in Cleveland on June 18-19.

Since the Ohio Cup started being settled in the regular season, the Indians have won six times to the Reds' four. The two teams split their slate of games down the middle four times.

The Bronx Bombers visit Cleveland for three games from June 25-27, with the Indians going to Yankee Stadium for three games August 24-26. The Indians went 3-4 against the Yankees.

The Indians will also be hosting the Marlins for their second trip to Progressive Field. Florida took two of three in 2004.

The Indians head to Fenway Park to play four games against Boston on May 10-13, then host the Red Sox for four games from Aug. 9-12. The Tribe swept the Red Sox in their second series this past year, finishing 6-4 against Boston.

There are two three-series West Coast trips, coming at the beginning and the end of the season. On the first trip, the Tribe travels to Kansas City, Seattle and Oakland for three games apiece from April 13-22 with an off-day on April 16.

The other trip out West runs from Aug. 13-22, with the team playing three games against the Angels, A's and Mariners, respectively.

The longest homestand of the season spans 10 games with the Yankees, A's and Rangers visiting Progressive Field, Oakland for four games.

Twenty-two of the final Indians' final 38 games will be played at home, and 18 of the first 30 are home games.

The Indians will close out the season with a six-game homestand, playing three against the Royals from Sept. 28-30, and three more against the White Sox from Oct. 1-3.

Louie Horvath is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.